Tag Clinical trial

treatment

The King under review

Critica appraisal of treatment studies We all know that the randomized clinical trial is the king of interventional methodological designs. It is the type of epidemiological study that allows a better control of systematic errors or biases, since the researcher…
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re-randomization

Regular customers

Re-randomization in clinical trials We saw in a previous post that sample size is very important. The sample should be the right size, neither more nor less. If too large, we are wasting resources, something to keep in mind in…
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run in period

Steady… ready…

Run in period Don’t!. Not so fast. Before you rush out there you have to be sure that everything is well prepared. It is difficult to conceive that anyone gets to run a marathon without preparing beforehand, without sufficient physical…
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factorial clinical trial

More than one rooster per pen

Factorial clinical trial The clinical trial is the king of epidemiological designs. But it is also the most expensive to perform. And, in our times, this is an important inconvenience to launch a trial. Usually in each trial an intervention…
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Intention-to-treat analysis

Intention is what matters

Intention-to-treat analysis Someone always does not do what he’s told. No matter how simple the approach of a clinical trial seems to be regarding to its participants. They are randomly assigned to one of the two arms of the trial…
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equivalence

The consolation of not being worse

Equivalence and non-inferiority We live in a frantic and highly competitive world. We are continually inundated with messages about how good it is to be the best in this and that. As indeed it is. But most of us soon…
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clinical trials

The other sides of the King

Types of clinical trials We’ve already talked at other times about the king of experimental designs, the randomized clinical trial, in which a population is randomly assigned into two groups to undergo the intervention under study, one of the groups,…
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Adaptive clinical trial

The chameleon

Adaptive clinical trial What a fascinating reptile. It’s known by its eyes, with its ability to rotate independently covering the whole angle of the circle. Also known is its long tongue, with which it traps from the distance the bug…
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pilot studies

About pilots

Pilot studies No doubt that the randomized clinical trial is the King of epidemiological designs when we want to show, for instance, the effectiveness of a treatment. The problem is that clinical trials are difficult and expensive to perform, so…
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Masking

To see well you must be blind

Masking It’s said that there’s none so blind than those that refuse to see. But it’s also true that wanting to see too much can be counterproductive. Sometimes it is better to see just the essential and indispensable. That’s what…
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