sample size

A strenuous effort, though unnecessary

Factors that condition the sample size Nowadays, the teaching of Medicine and, in general, teaching at the university level, is quite well defined and standardized. And this is not only at a national level, but also at the level of our international environment. But this has not always been the case. In the beginning, each one went his own way and there was diversity in the ways and objectives of teaching, as you will see in the little story that I am going to tell in this post. A bit of history At the end of the 19th century and…
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The tribulations of maturity

Correct use of NNT Once upon a time, the scientific paradigms and the way of thinking of researchers (and also of clinicians) began to change, from “we’re doing well” to really wanting to know what was the validity of the information they collected in their experiments or in their daily practice. It is in this context that, 33 years ago, what would become one of the lords of the impact measures of clinical studies came to light: the number needed to treat, known worldwide by its acronym, NNT. Number needed to treat (NNT) Its initial usefulness was to assess the…
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Fisher's exact test

A story of tea and numbers

Fisher’s exact test Today we are going to remember one of the most beautiful stories, in my humble opinion, in the history of biostatistics. Although surely there are better stories, since my general historical ignorance is greater than the number of decimal places of the number pi. A story of tea and numbers Imagine we are at Rothamsted Station, an agricultural research center located in Harpenden, in the English county of Hertfordshire. We are at some moment in the beginning of the decade of the 20s of the last century. Three scientists, very British themselves, are preparing to have tea.…
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number remaining at risk

And what about me?

Number remaining at risk Today we are going to do an act of social justice. At least from the point of view of analyzing the results of clinical trials. You will wonder what the post of today is about. Well, everyone knows that when we try a new treatment for a disease, the first thing we want to know is how many patients we cure, for example, of that disease, or how many we prevent from dying from the disease. Imagine that, along with 99 other individuals, you participate in a clinical trial. Ultimately, 2 deaths are prevented with the…
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fragility, stability and clinical relevance

Take off your blinders

Fragility, stability and clinical relevance Blinders are pieces that are put over the eyes of some draft animals, such as donkeys or horses. Its purpose is none other than to get the animal to focus only on the road ahead, without being distracted by other things that it could see through its peripheral vision, less important for its task. I always feel a bit sad to see them like that, pulling the chariot with his eyes half covered. But, making an effort, I can understand the usefulness of the device, especially in areas with heavy traffic, where the animal could be frightened…
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