Like life itself
Pragmatic clinical trial. We all know how difficult it is to make a new drug available to people who can benefit from it. From the moment a promising molecule is identified and somebody thinks that it may be useful, until…
Science without sense...double nonsense
Evidence Based Medicine pills
Science without sense...double nonsense
Evidence Based Medicine pills
Read MoreLike life itself
A strenuous effort, though unnecessary
Factors that condition the sample size. The need to perform a correct calculation of the sample size necessary for a study is reviewed, as well as the main factors that influence the sample required to demonstrate the effect considered relevant…
The tribulations of maturity
Correct use of NNT. The NNT was designed to assess the beneficial effect of a treatment to reduce the risk of an unpleasant event occurring in an intervention group of interest, always with respect to what was observed in a…
A story of tea and numbers
Fisher’s exact test. Fisher’s test is the exact method used when you want to study if there is an association between two qualitative variables, that is, if the proportions of one variable are different depending on the value of the…
And what about me?
Number remaining at risk. The number needed to treat is the most widely used measure of clinical impact in the analysis of the results of a clinical trial. However, the prognosis of patients in whom the outcome under study does…