Tag Basic concepts

The King under review

Critica appraisal of treatment studies We all know that the randomized clinical trial is the king of interventional methodological designs. It is the type of epidemiological study that allows a better control of systematic errors or biases, since the researcher…
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King of Kings

Randomized clinical trial There is no doubt that when doing a research in biomedicine we can choose from a large number of possible designs, all with their advantages and disadvantages. But in such a diverse and populous court, among jugglers,…
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Regular customers

Re-randomization in clinical trials We saw in a previous post that sample size is very important. The sample should be the right size, neither more nor less. If too large, we are wasting resources, something to keep in mind in…
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Steady… ready…

Don’t!. Not so fast. Before you rush out there you have to be sure that everything is well prepared. It is difficult to conceive that anyone gets to run a marathon without preparing beforehand, without sufficient physical fitness and nutrition.…
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More than one rooster per pen

Factorial clinical trial The clinical trial is the king of epidemiological designs. But it is also the most expensive to perform. And, in our times, this is an important inconvenience to launch a trial. Usually in each trial an intervention…
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The gregarious one

Cluster clinical trials Conventional randomized clinical trial is an individualistic design, in which each participant is randomized to receive the intervention or placebo to measure the outcome variable after each and compare the differences. This single randomization is complemented by…
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Intention is what matters

Intention-to-treat analysis Someone always does not do what he’s told. No matter how simple the approach of a clinical trial seems to be regarding to its participants. They are randomly assigned to one of the two arms of the trial…
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The other sides of the King

We’ve already talked at other times about the king of experimental designs, the randomized clinical trial, in which a population is randomly assigned into two groups to undergo the intervention under study, one of the groups, and to serve as…
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To what do you attribute it?

It seems like only yesterday. I began my adventures at the hospital and had my first contacts with The Patient. And, by the way, I didn’t know much about diseases but I knew without thinking about it what were the…
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